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1

Altered profile of human gut microbiome is associated with cirrhosis and its complications

Bajaj, Jasmohan S., Heuman, Douglas M., Hylemon, Phillip B., Sanyal, Arun J., White, Melanie B., Monteith, Pamela, Noble, Nicole A., Unser, Ariel B., Daita, Kalyani, Fisher, Andmorgan R., Sikaroodi, M

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

2

Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes

W.David Jarvis, Kelly L Auer, Mark Spector, George Kunos, Steven Grant, Philip Hylemon, Ross Mikkelsen, Paul Dent

Journal:

Year:

1997

Language:

english

File:

PDF, 799 KB

english, 1997

3

313 25-Hydroxycholesterol-3-Sulfate (25HC3S) Attenuates Hepatocyte Intracellular Lipid Levels and Inflammatory Response via LXR/Srebps and IKB/NF-kB Pathways

Xu, Leyuan, Bai, Qianming, Hylemon, Phillip, Heuman, Douglas M., Pandak, William M., Ren, Shunlin

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

4

Endoplasmic Reticulum Stress and Atherosclerosis

Zhou, Huiping, Sun, Lixin, Xiao, Jian, Zhang, Luyong, Li, Xiaokun, Studer, Elaine, Pandak, William, Hylemon, Phillip

Journal:

Current Hypertension Reviews

Year:

2010

Language:

english

File:

PDF, 281 KB

english, 2010

5

Gut microbiota drive the development of neuro-inflammatory response in cirrhosis

Kang, Dae Joong, Betrapally, Naga S, Ghosh, Siddhartha A, Sartor, R Balfour, Hylemon, Phillip B, Gillevet, Patrick M, Sanyal, Arun J, Heuman, Douglas M, Carl, Daniel, Zhou, Huiping, Liu, Runping, Wang

Journal:

Year:

2016

Language:

english

File:

PDF, 3.56 MB

english, 2016

6

7 α-Dehydroxylation of cholic acid by cell extracts of Eubacterium species V.P.I. 12708

Hylemon, P B, Cacciapuoti, A F, White, B A, Whitehead, T R, Fricke, R J

Journal:

American Journal of Clinical Nutrition

Year:

1980

Language:

english

File:

PDF, 484 KB

english, 1980

7

Consequences of bile salt biotransformations by intestinal bacteria

Ridlon, Jason M., Harris, Spencer C., Bhowmik, Shiva, Kang, Dae-Joong, Hylemon, Phillip B.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.77 MB

english, 2016

8

Metabolism of hydrogen gases and bile acids in the gut microbiome

Hylemon, Phillip B., Harris, Spencer C., Ridlon, Jason M.

Journal:

Year:

2018

Language:

english

File:

PDF, 618 KB

english, 2018

9

Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes

Shunlin Ren, Xiaobo Li, Daniel Rodriguez-Agudo, Gregorio Gil, Phillip Hylemon, William M. Pandak

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 222 KB

english, 2007

10

Regulation of bile acid synthesis

Z. Reno Vlahcevic, Douglas M. Heuman, Phillip B. Hylemon

Journal:

Year:

1991

Language:

english

File:

PDF, 1.34 MB

english, 1991

11

Expression of the bile acid-inducible NADH:flavin oxidoreductase gene of Eubacterium sp. VPI 12708 in Escherichia coli

Stephen F. Baron, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1995

Language:

english

File:

PDF, 1023 KB

english, 1995

12

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, Genta, Pandak, William M., Gillevet, Patrick M., Hylemon, Phillip B., Heuman, Douglas M., Daita, Kalyani, Takei, Hajime, Muto, Akina, Nittono, Hiroshi, Ridlon, Jason M., White, Melanie B., N

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 655 KB

english, 2013

13

280 The Beneficial Impact of Rifaximin on Systemic and Intestinal Inflammation and Ammonia Occurs Even Without Microbiota: More Than an Antibiotic

Kang, Daejoong, Sartor, R. Balfour, Kakiyama, Genta, Betrapally, Naga, Herzog, Jeremy, Nittono, Hiroshi, Hylemon, Phillip, Zhou, Huiping, Carroll, Ian, Yang, Jin, Gillevet, Patrick M., Jiao, Chunhua,

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 870 KB

english, 2016

14

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages

Zha, Weibin, Wang, Guangji, Xu, Weiren, Liu, Xuyuan, Wang, Yun, Zha, Beth S., Shi, Jian, Zhao, Qijin, Gerk, Phillip M., Studer, Elaine, Hylemon, Phillip B., Pandak, William M., Zhou, Huiping, Zhao, Ri

Journal:

Year:

2013

Language:

english

File:

PDF, 735 KB

english, 2013

15

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Yang, Jing, Sun, Lixin, Wang, Lu, Hassan, Hozeifa M., Wang, Xuan, Hylemon, Phillip B., Wang, Tao, Zhou, Huiping, Zhang, Luyong, Jiang, Zhenzhou

Journal:

Frontiers in Pharmacology

Year:

2017

Language:

english

File:

PDF, 5.36 MB

english, 2017

16

Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis

E.J. Stellwag, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1976

Language:

english

File:

PDF, 658 KB

english, 1976

17

695 18ß-Glycyrrhetinic Acid Prevents Free Fatty Acid-Induced Hepatic Lipotoxicity by Upregulating GRP78 Expression

Li, Yunzhou, Zhang, Xiaoxuan, Wang, Guangji, Gurley, Emily C., Hylemon, Phillip, Pandak, William M., Zhou, Huiping

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 176 KB

english, 2012

18

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

Mitchell, C., Park, M. A., Zhang, G., Han, S. I., Harada, H., Franklin, R. A., Yacoub, A., Li, P.-L., Hylemon, P. B., Grant, S., Dent, P.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 712 KB

english, 2007

19

Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens

Ridlon, J. M., Ikegawa, S., Alves, J. M. P., Zhou, B., Kobayashi, A., Iida, T., Mitamura, K., Tanabe, G., Serrano, M., De Guzman, A., Cooper, P., Buck, G. A., Hylemon, P. B.

Journal:

The Journal of Lipid Research

Year:

2013

Language:

english

File:

PDF, 1.73 MB

english, 2013

20

The catabolism of cholesterol

Stravitz, R. Todd, Hylemon, Phillip B., Vlahcevic, Z. Reno

Journal:

Current Opinion in Lipidology

Year:

1993

File:

PDF, 631 KB

1993

21

Erratum: Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

Bajaj, Jasmohan S., Betrapally, Naga S., Hylemon, Phillip B., Thacker, Leroy R., Daita, Kalyani, Kang, Dae Joong, White, Melanie B., Unser, Ariel B., Fagan, Andrew, Gavis, Edith A., Sikaroodi, Masoume

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 110 KB

english, 2016

22

Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis

Hall, E., Hylemon, P., Vlahcevic, Z., Mallonee, D., Valerie, K., Avadhani, N., Pandak, W.

Journal:

American Journal of Physiology - Gastrointestinal and Liver Physiology

Year:

2001

File:

PDF, 309 KB

2001

23

Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis

Hall, E., Hylemon, P., Vlahcevic, Z., Mallonee, D., Valerie, K., Avadhani, N., Pandak, W.

Journal:

American Journal of Physiology - Gastrointestinal and Liver Physiology

Year:

2001

Language:

english

File:

PDF, 309 KB

english, 2001

24

Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes

Wang, Yanyan, Zhou, Xiqiao, Zhao, Derrick, Wang, Xuan, Gurley, Emily C., Liu, Runping, Li, Xiaojiaoyang, Hylemon, Phillip B., Chen, Weidong, Zhou, Huiping, Alpini, Gianfranco D.

Journal:

Year:

2020

File:

PDF, 2.22 MB

2020

25

Characterization of a NADH:Flavin oxidoreductase induced by cholic acid in a 7α-dehydroxylating intestinal Eubacterium species

Robert H. Lipsky, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1980

Language:

english

File:

PDF, 508 KB

english, 1980

26

The Genus Spirillum: a Taxonomic Study

HYLEMON, P. B., WELLS, J. S., KRIEG, N. R., JANNASCH, H. W.

Journal:

International Bulletin of Bacteriological Nomenclature and Taxonomy

Year:

1973

Language:

english

File:

PDF, 24.37 MB

english, 1973

27

Sterol 27-hydroxylase is a tissue specific regulator of cholesterol and bile acid synthesis

Hall, Elizabeth A., Vlahcevic, Zdravko R., Hylemon, Phillip B., Mallonee, Darrell, Pandak, William M.

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 203 KB

english, 2000

28

S1589 Alcohol Promotes HIV Protease Inhibitor-Induced Hepatoxicity By Activating the ER Stress Response in Hepatocytes

Wu, Xudong, Cao, Risheng, Sun, Lixin, Zha, Weibin, Pecora, Beth S., Gurley, Emily C., Studer, Elaine, Hylemon, Phillip, Pandak, William M., Sanyal, Arun J., Zhang, Luyong, Zhou, Huiping

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 61 KB

english, 2009

29

Identification and Characterization of a Bile Acid 7alpha -Dehydroxylation Operon in Clostridium sp. Strain TO-931, a Highly Active 7alpha -Dehydroxylating Strain Isolated from Human Feces

Wells, J. E., Hylemon, P. B.

Journal:

Applied and Environmental Microbiology

Year:

2000

Language:

english

File:

PDF, 369 KB

english, 2000

30

Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes: ROLE OF ACIDIC SPHINGOMYELINASE-MEDIATED CERAMIDE GENERATION IN FAS RECEPTOR ACTIVATION

Gupta, S., Natarajan, R., Payne, S. G., Studer, E. J., Spiegel, S., Dent, P., Hylemon, P. B.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 772 KB

english, 2004

31

Alterations in Gut Microbial Function Following Liver Transplant

Bajaj, Jasmohan S., Kakiyama, Genta, Cox, I. Jane, Nittono, Hiroshi, Takei, Hajime, White, Melanie, Fagan, Andrew, Gavis, Edith A., Heuman, Douglas M., Gilles, Ho Chong, Hylemon, Phillip, Taylor-Robin

Journal:

Liver Transplantation

Year:

2018

Language:

english

File:

PDF, 963 KB

english, 2018

32

Gut microbial RNA and DNA analysis predicts hospitalizations in cirrhosis

Bajaj, Jasmohan S., Thacker, Leroy R., Fagan, Andrew, White, Melanie B., Gavis, Edith A., Hylemon, Phillip B., Brown, Robert, Acharya, Chathur, Heuman, Douglas M., Fuchs, Michael, Dalmet, Swati, Sikar

Journal:

Year:

2018

Language:

english

File:

PDF, 961 KB

english, 2018

33

Specific Gut and Salivary Microbiota Patterns Are Linked With Different Cognitive Testing Strategies in Minimal Hepatic Encephalopathy

Bajaj, Jasmohan S., Fagan, Andrew, White, Melanie B., Wade, James B., Hylemon, Phillip B., Heuman, Douglas M., Fuchs, Michael, John, Binu V., Acharya, Chathur, Sikaroodi, Masoumeh, Gillevet, Patrick M

Journal:

American Journal of Gastroenterology

Year:

2019

File:

PDF, 1.16 MB

2019

34

P

Acharya, Chathur, Salzman, Nita, Genta,, Sikaroodi, Masoumeh, Hayward, Michael, Fagan, Andrew, Gavis, Edith A., White, Melanie, Takei, Hajime, Nittono, Hiroshi, Pandak, William M., Hylemon, Phillip B

Journal:

American Journal of Gastroenterology

Year:

2019

File:

PDF, 6.27 MB

2019

35

Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat

Douglas M. Heuman, Z. Reno Vlahcevic, Marsha L. Bailey, Phillip B. Hylemon

Journal:

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

36

Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to reduced cell cycle progression

Liang Qiao, Kevin Leach, Robert McKinstry, Donna Gilfor, Adly Yacoub, Jong Sung Park, Steven Grant, Philip B. Hylemon, Paul B. Fisher, Paul Dent

Journal:

Year:

2001

Language:

english

File:

PDF, 431 KB

english, 2001

37

Characterization of †4-3-ketosteroid-5β-reductase and 3β-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum

N.A. Stokes, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1985

Language:

english

File:

PDF, 593 KB

english, 1985

38

Characterization of a C21 neutral steroid hormone transforming enzyme, 21-dehydroxylase, in crude cell extracts of Eubacterium lentum

S.D. Feighner, V.D. Bokkenheuser, J. Winter, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1979

Language:

english

File:

PDF, 705 KB

english, 1979

39

Expression of Sterol 12α-Hydroxylase Alters Bile Acid Pool Composition in Primary Rat Hepatocytes and In Vivo

William M. Pandak, Patricia Bohdan, Clifton Franklund, Darrell H. Mallonee, Gösta Eggertsen, Ingemar Björkhem, Gregorio Gil, Z. Reno Vlahcevic, Phillip B. Hylemon

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 787 KB

english, 2001

40

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

Bajaj, Jasmohan S., Betrapally, Naga S., Hylemon, Phillip B., Heuman, Douglas M., Daita, Kalyani, White, Melanie B., Unser, Ariel, Thacker, Leroy R., Sanyal, Arun J., Kang, Dae Joong, Sikaroodi, Masou

Journal:

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

41

Gut Microbiota, Cirrhosis, and Alcohol Regulate Bile Acid Metabolism in the Gut

Ridlon, Jason M., Kang, Dae-Joong, Hylemon, Phillip B., Bajaj, Jasmohan S.

Journal:

Digestive Diseases

Year:

2015

Language:

english

File:

PDF, 202 KB

english, 2015

42

Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7 -dehydroxylating intestinal bacterium

Ridlon, J. M., Hylemon, P. B.

Journal:

The Journal of Lipid Research

Year:

2012

Language:

english

File:

PDF, 1.70 MB

english, 2012

43

The Beneficial Impact of Rifaximin on Systemic and Intestinal Inflammation and Ammonia Occurs even without Microbiota: More than an Antibiotic

Kang, D.J., Balfour Sartor, R., Betrapally, N., Nittono, H., Herzog, J., Hylemon, P., SIkaroodi, M., Gillevet, P., Carroll, I., Kakiyama, G., Zhou, H., Yang, J., Jiao, C., Fan, S., Fiehn, O., Takei, H

Journal:

Journal of Hepatology

Year:

2016

Language:

english

File:

PDF, 107 KB

english, 2016

44

Diet Affects Gut Microbiota and Modulates Hospitalization Risk Differentially In an International Cirrhosis Cohort

Bajaj, Jasmohan S, Idilman, Ramazan, Mabudian, Leila, Hood, Matthew, Fagan, Andrew, Turan, Dilara, White, Melanie B, Karakaya, Fatih, Wang, Jessica, Atalay, Rengül, Hylemon, Phillip B, Gavis, Edith A,

Journal:

Year:

2018

Language:

english

File:

PDF, 1.74 MB

english, 2018

45

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

Qianming Bai, Leyuan Xu, Genta Kakiyama, Melissa Ann Runge-Morris, Phillip B. Hylemon, Lianhua Yin, William M. Pandak, Shunlin Ren

Journal:

Atherosclerosis

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

46

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., Puri, P., Sterling, R. K., Luketic, V., Stravitz, R. T., Siddiqui, M. S., Fuchs, M., Thacker, L. R., Wade, J. B., Daita, K., Sistrun, S., Wh

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 457 KB

english, 2014

47

Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function

Bajaj, J. S., Cox, I. J., Betrapally, N. S., Heuman, D. M., Schubert, M. L., Ratneswaran, M., Hylemon, P. B., White, M. B., Daita, K., Noble, N. A., Sikaroodi, M., Williams, R., Crossey, M. M. E., Tay

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2014

Language:

english

File:

PDF, 411 KB

english, 2014

48

Bile Acid Regulation of C/EBP , CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

Qiao, L., Han, S. I., Fang, Y., Park, J. S., Gupta, S., Gilfor, D., Amorino, G., Valerie, K., Sealy, L., Engelhardt, J. F., Grant, S., Hylemon, P. B., Dent, P.

Journal:

Molecular and Cellular Biology

Year:

2003

Language:

english

File:

PDF, 678 KB

english, 2003

49

The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical Implications

Flint, O. P., Noor, M. A., Hruz, P. W., Hylemon, P. B., Yarasheski, K., Kotler, D. P., Parker, R. A., Bellamine, A.

Journal:

Toxicologic Pathology

Year:

2009

Language:

english

File:

PDF, 601 KB

english, 2009

50

Characterization of 7-α-dehydroxylase in Clostridium leptum

Stellwag, E. J., Hylemon, P. B.

Journal:

American Journal of Clinical Nutrition

Year:

1978

Language:

english

File:

PDF, 607 KB

english, 1978

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